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Article

The Human Immunodeficiency Virus Type 1<i>gag</i>Gene Encodes an Internal Ribosome Entry Site

1 Jan 2001

Abstract excerpt

Several retroviruses have recently been shown to promote translation of their gag gene products by internal ribosome entry. In this report, we show that mRNAs containing the human immunodeficiency virus type 1 (HIV-1) gag open reading frame (ORF) exhibit internal ribosome entry site (IRES) activity that can promote translational initiation of Pr55(gag). Remarkably, this IRES activity is driven by sequences within...

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PMID: 11119587
DOI: 10.1128/jvi.75.1.181-191.2001

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