Article

HIV-1 <i>gag-pol</i> mRNA localization regulates the site of virion assembly

2016-06-09

Abstract excerpt

<h4>ABSTRACT</h4> HIV-1 full-length, unspliced genomic RNAs (gRNAs) serve both as mRNAs encoding the Gag and Gag-Pol capsid proteins as well as the genetic material packaged by Gag into virions that assemble at the plasma membrane (PM). Whether localized Gag synthesis contributes to assembly at the PM is unknown. Here we show that artificially tethering gRNAs or surrogate gag -pol mRNAs to non-PM membranes or th...

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Identifiers and source

Literature Corpus work: 49334e09-3dbe-56cd-aa24-98ff53ef43dd
DOI: 10.1101/057299

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