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A new type of IRES within gag coding region recruits three initiation complexes on HIV-2 genomic RNA

4 Dec 2009

Abstract excerpt

Genomic RNA of primate lentiviruses serves both as an mRNA that encodes Gag and Gag-Pol polyproteins and as a propagated genome. Translation of this RNA is initiated by standard cap dependant mechanism or by internal entry of the ribosome. Two regions of the genomic RNA are able to attract initiation complexes, the 5' untranslated region and the gag coding region itself. Relying on probing data and a phylogenetic...

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PMID: 19969542
DOI: 10.1093/nar/gkp1109

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