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The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence.

Microbiology (Reading, England) - 1 Jul 2000

Chalker Alison F, Ingraham Karen A, Lunsford R Dwayne, Bryant Alexander P, Bryant Joanna, Wallis Nicola G, Broskey John P, Pearson Stewart C, Holmes David J

Abstract excerpt

Homologues of Escherichia coli bacA, encoding extremely hydrophobic proteins, were identified in the genomes of Staphylococcus aureus and Streptococcus pneumoniae. Allelic replacement mutagenesis demonstrated that the gene is not essential for in vitro growth in either organism, and the mutants showed no significant changes in growth rate or morphology. The Staph. aureus bacA mutant showed slightly reduced...

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PMID: 10878119
DOI: 10.1099/00221287-146-7-1547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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