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Article

Single-copy IMH3 allele is sufficient to confer resistance to mycophenolic acid in Candida albicans and to mediate transformation of clinical Candida species.

Infection and immunity - 1 Jan 2001

Beckerman J, Chibana H, Turner J, Magee P T

Abstract excerpt

Parasexual genetic analysis of Candida albicans utilized the dominant selectable marker that conferred resistance to mycophenolic acid. We cloned and sequenced the IMH3(r) gene from C. albicans strain 1006, which was previously identified as resistant to mycophenolic acid (MPA) (A. K. Goshorn and S. Scherer, Genetics 123:213-218, 1989). MPA is an inhibitor of IMP dehydrogenase, an enzyme necessary for the de novo...

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Identifiers

PMID: 11119495
DOI: 10.1128/IAI.69.1.108-114.2001
PMCID: PMC97861

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