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Article

Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1.

Antimicrobial agents and chemotherapy - 1 Aug 2012

Sasse Christoph, Schillig Rebecca, Reimund Alexandra, Merk Julia, Morschhäuser Joachim

Abstract excerpt

Overexpression of the multidrug efflux pump MDR1 confers resistance to the antifungal drug fluconazole on Candida albicans. It has been reported that two types of MDR1 promoters exist in C. albicans and that homozygosity for the allele with higher activity may promote fluconazole resistance. We found that the two MDR1 promoter alleles in strain SC5314 were equally well activated by inducing chemicals or...

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Source

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Identifiers

PMID: 22615278
DOI: 10.1128/AAC.00264-12
PMCID: PMC3421547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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