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Article

Targeted neuronal gene expression and longevity in Drosophila.

Experimental gerontology - 1 Dec 2000

Phillips J P, Parkes T L, Hilliker A J

Abstract excerpt

Earlier studies from this laboratory have shown that in the insect, Drosophila melanogaster, the motorneuron is an important cellular nexus between the metabolism of reactive oxygen species (ROS) and adult lifespan. This was demonstrated by experiments in which expression of CuZn SOD (SOD1) specifically in motorneurons was shown to extend the mean and maximum adult lifespans to 140% of normal, and to rescue the...

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Source

Identifiers

PMID: 11113599
DOI: 10.1016/s0531-5565(00)00117-0

Genes

SOD1
SOD2
CAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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