Article
Expression of human FALS SOD in motorneurons of Drosophila.
Free radical biology & medicine - 1 May 1999
Elia A J, Parkes T L, Kirby K, St George-Hyslop P, Boulianne G L, Phillips J P, Hilliker A J
Abstract excerpt
Mutations in human CuZn superoxide dismutase (SOD) have been associated with familial amyotrophic lateral sclerosis (FALS). Although leading to many experimental advances, this finding has not yet led to a clear understanding of the biochemical mechanism by which mutations in SOD promote the degeneration of motorneurons that causes this incurable paralytic disease. To explore the biochemical mechanism of FALS...
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