Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 2001

Melov S, Doctrow S R, Schneider J A, Haberson J, Patel M, Coskun P E, Huffman K, Wallace D C, Malfroy B

Abstract excerpt

Superoxide is produced as a result of normal energy metabolism within the mitochondria and is scavenged by the mitochondrial form of superoxide dismutase (sod2). Mice with inactivated SOD2 (sod2 nullizygous mice) die prematurely, exhibiting several metabolic and mitochondrial defects and severe tissue pathologies, including a lethal spongiform neurodegenerative disorder (Li et al., 1995; Melov et al., 1998,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Catalase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Administration Schedule

Share to Free Radical Scavengers

Share to Injections, Intraperitoneal

Share to Neurodegenerative Diseases

Share to Organometallic Compounds

Share to Salicylates

Source

Open in PubMed Open full text

Identifiers

PMID: 11606622
PMCID: PMC6762800

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics.PMID 11606622Read ↗

Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging.Semantic proximity Read ↗

Superoxide dismutase, aging, and degenerative disease.Semantic proximity Read ↗

Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis modelSemantic proximity Read ↗

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans.Semantic proximity Read ↗

Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.Semantic proximity Read ↗

Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegansSemantic proximity Read ↗

Mitochondrial superoxide acts in the intestine to extend longevitySemantic proximity Read ↗

Superoxide dismutase is dispensable for normal animal lifespan.Semantic proximity Read ↗

Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment.Semantic proximity Read ↗

Targeted neuronal gene expression and longevity in Drosophila.Semantic proximity Read ↗

A Measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.