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Article

Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.

Neurobiology of aging - 1 Oct 2013

Bahadorani Sepehr, Mukai Spencer T, Rabie Jason, Beckman Joseph S, Phillips John P, Hilliker Arthur J

Abstract excerpt

More than 130 different mutations in the Cu/Zn superoxide dismutase (SOD1) gene have been associated with amyotrophic lateral sclerosis but the mechanism of this toxicity remains controversial. To gain insight into the importance of the zinc site in the pathogenesis of SOD1 in vivo, we generated...

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Identifiers

PMID: 23601674
DOI: 10.1016/j.neurobiolaging.2013.03.024
PMCID: PMC4145400

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23601674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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