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Article

Isolation of a high affinity scFv from a monoclonal antibody recognising the oncofoetal antigen 5T4.

Biochimica et biophysica acta - 15 Dec 2000

Shaw D M, Embleton M J, Westwater C, Ryan M G, Myers K A, Kingsman S M, Carroll M W, Stern P L

Abstract excerpt

The oncofoetal antigen 5T4 is a 72 kDa glycoprotein expressed at the cell surface. It is defined by a monoclonal antibody, mAb5T4, that recognises a conformational extracellular epitope in the molecule. Overexpression of 5T4 antigen by tumours of several types has been linked with disease progression and poor clinical outcome. Its restricted expression in non-malignant tissue makes 5T4 antigen a suitable target...

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PMID: 11113573
DOI: 10.1016/s0304-4165(00)00165-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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