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Genetic modification of mesenchymal stem cells to express a single-chain antibody against EGFRvIII on the cell surface

24 Nov 2009

Abstract excerpt

Human adult mesenchymal stem cells (hMSCs) are under active investigation as cellular carriers for gene therapy. hMSCs possess natural tropism toward tumours; however, the targeting of hMSCs to specific cell populations within tumours is unexplored. In the case of glioblastoma multiforme (GBM), at least half of the tumours express EGFRvIII on the cell surface, an ideal target for antibody-mediated gene/drug...

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PMID: 19937911
DOI: 10.1002/term.228

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