Article
[Primary liver cell carcinoma as complication of alpha 1-antitrypsin deficiency in a 67 year old man].
Nederlands tijdschrift voor geneeskunde - 18 Nov 2000
van den Hazel S J, Meijer J W, van den Elshout F J, de Vries R A
Abstract excerpt
A 67-year-old male patient with pulmonary emphysema was diagnosed with liver cirrhosis. Further investigations revealed an alpha 1-antitrypsin deficiency caused by a PiZZ mutation. The liver cirrhosis was complicated by the development of a hepatocellular carcinoma. The patient died from the consequences of mesentary vein thrombosis. The protease inhibitor alpha 1-antitrypsin controls the tissue damaging effects...
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