Article
Oxidative stress and AP-1 activity in tamoxifen-resistant breast tumors in vivo.
Journal of the National Cancer Institute - 6 Dec 2000
Schiff R, Reddy P, Ahotupa M, Coronado-Heinsohn E, Grim M, Hilsenbeck S G, Lawrence R, Deneke S, Herrera R, Chamness G C, Fuqua S A, Brown P H, Osborne C K
Abstract excerpt
BACKGROUND: Most breast cancers, even those that are initially responsive to tamoxifen, ultimately become resistant. The molecular basis for this resistance, which in some patients is thought to involve stimulation of tumor growth by tamoxifen, is unclear. Tamoxifen induces cellular oxidative stress, and because changes in cell redox state can activate signaling pathways leading to the activation of activating...
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