Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2000

Sligh J E, Levy S E, Waymire K G, Allard P, Dillehay D L, Nusinowitz S, Heckenlively J R, MacGregor G R, Wallace D C

Abstract excerpt

We report a method for introducing mtDNA mutations into the mouse female germ line by means of embryonic stem (ES) cell cybrids. Mitochondria were recovered from the brain of a NZB mouse by fusion of synaptosomes to a mtDNA-deficient (rho degrees ) cell line. These cybrids were enucleated and the cytoplasts were electrofused to rhodamine-6G (R-6G)-treated female ES cells. The resulting ES cell cybrids permitted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chimera
Share to Chloramphenicol

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genomic Imprinting

Share to Myocardium

Share to Retinal Cone Photoreceptor Cells

Share to Retinal Rod Photoreceptor Cells

Share to Stem Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 11106380
DOI: 10.1073/pnas.250491597
PMCID: PMC18941

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice.PMID 11106380Read ↗

Transfer of chloramphenicol-resistant mitochondrial DNA into the chimeric mouse.Semantic proximity Read ↗

Production of homoplasmic xenomitochondrial miceSemantic proximity Read ↗

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation.Semantic proximity Read ↗

Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells.Semantic proximity Read ↗

Transmitochondrial cybrids: tools for functional studies of mutant mitochondria.Semantic proximity Read ↗

Expression of Rattus norvegicus mtDNA in Mus musculus cells results in multiple respiratory chain defects.Semantic proximity Read ↗

Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.Semantic proximity Read ↗

Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model.Semantic proximity Read ↗

Selective elimination of mitochondrial mutations in the germline by genome editing.Semantic proximity Read ↗

Amelioration of Leigh syndrome induced by mouse blastocyst complementation with a mutant human mitochondrial ATP synthase 6Semantic proximity Read ↗

Production of mitochondrial DNA transgenic mice using zygotes.Semantic proximity Read ↗

Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.