Article
The XRCC1 399 glutamine allele is a risk factor for adenocarcinoma of the lung.
Mutation research - 5 Jan 2001
Divine K K, Gilliland F D, Crowell R E, Stidley C A, Bocklage T J, Cook D L, Belinsky S A
Abstract excerpt
Defects in the repair and maintenance of DNA increase risk for cancer. X-ray cross-complementing group 1 protein (XRCC1) is involved with the repair of DNA single-strand breaks. A nucleotide substitution of guanine to adenine leading to a non-conservative amino acid change was identified in the XRCC1 gene at codon 399 (Arg/Gln). This change is associated with higher levels of aflatoxin B1-adducts and glycophorin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.