Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasia

1 Dec 2000

Abstract excerpt

Smooth muscle (SM) develops only in organs and sites that sustain mechanical tensions. Therefore, we determined the role of stretch in mouse and human bronchial myogenesis. Sustained stretch induced expression of SM proteins in undifferentiated mesenchymal cells and accelerated the differentiation of cells undergoing myogenesis. Moreover, bronchial myogenesis was entirely controlled in lung organ cultures by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neonatal Respiratory Health Research
Share to Neurogenetic and Muscular Disorders Research
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11104785
DOI: 10.1172/jci8893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stretch-induced alternative splicing of serum response factor promotes bronchial myogenesis and is defective in lung hypoplasiaPMID 11104785Read ↗

Serum Response Factor Expression in Excess Permits a Dual Contractile-Proliferative Phenotype of Airway Smooth Muscle.Semantic proximity Read ↗

Molecular changes during TGFβ-mediated lung fibroblast-myofibroblast differentiation: implication for glucocorticoid resistanceSemantic proximity Read ↗

Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activationSemantic proximity Read ↗

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung FibroblastsSemantic proximity Read ↗

Stretch Regulates Alveologenesis and Homeostasis Via Mesenchymal G <sub>αq/11</sub> -Mediated TGFβ2 ActivationSemantic proximity Read ↗

Identification of cellular processes that are rapidly modulated in response to tracheal occlusion within mice lungs.Semantic proximity Read ↗

High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis.Semantic proximity Read ↗

Contractility and phenotype of human bronchiole smooth muscle after prolonged fetal bovine serum exposure.Semantic proximity Read ↗

Can we differentiate between airway and vascular smooth muscle?Semantic proximity Read ↗

The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells.Semantic proximity Read ↗

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.Semantic proximity Read ↗

Enhanced upregulation of smooth muscle related transcripts by TGF 2 in asthmatic (myo) fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.