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Article

High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis.

The Journal of cell biology - 4 Mar 2002

Beqaj Safedin, Jakkaraju Sandhya, Mattingly Raymond R, Pan Desi, Schuger Lucia

Abstract excerpt

Round embryonic mesenchymal cells have the potential to differentiate into smooth muscle (SM) cells upon spreading/elongation (Yang, Y., K.C. Palmer, N. Relan, C. Diglio, and L. Schuger. 1998. Development. 125:2621-2629; Yang, Y., N.K. Relan, D.A. Przywara, and L. Schuger. 1999. Development. 126:3027-3033; Yang, Y., S. Beqaj, P. Kemp, I. Ariel, and L. Schuger. 2000. J. Clin. Invest. 106:1321-1330). In the...

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PMID: 11877460
DOI: 10.1083/jcb.200107049
PMCID: PMC2173321

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