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Article

The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells.

Pediatric research - 1 Jun 2010

Foster Cherie D, Varghese Linda S, Gonzales Linda W, Margulies Susan S, Guttentag Susan H

Abstract excerpt

Stretch is an essential mechanism for lung growth and development. Animal models in which fetal lungs have been chronically over or underdistended demonstrate a disrupted mix of type II and type I cells, with static overdistention typically promoting a type I cell phenotype. The Rho GTPase family, key regulators of cytoskeletal signaling, are known to mediate cellular differentiation in response to stretch in...

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Identifiers

PMID: 20220547
DOI: 10.1203/PDR.0b013e3181dbc708
PMCID: PMC3063400

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PGC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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