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Article

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

Molecular and cellular biology - 1 Sept 1991

Cheng Y S, Patterson C E, Staeheli P

Abstract excerpt

The primary structures of interferon (IFN)-induced guanylate-binding proteins (GBPs) were deduced from cloned human and murine cDNAs. These proteins contained only two of the three sequence motifs typically found in GTP/GDP-binding proteins. The N(T)KXD motif, which is believed to confer guanine specificity in other nucleotide-binding proteins, was absent. Nevertheless, the IFN-induced GBPs exhibited a high...

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Identifiers

PMID: 1715024
DOI: 10.1128/mcb.11.9.4717-4725.1991
PMCID: PMC361367

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