Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

doi:10.1128/mcb.11.9.4717-4725.1991

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Article

Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.

Molecular and cellular biology - 1 Sept 1991

Cheng Y S, Patterson C E, Staeheli P

Abstract excerpt

The primary structures of interferon (IFN)-induced guanylate-binding proteins (GBPs) were deduced from cloned human and murine cDNAs. These proteins contained only two of the three sequence motifs typically found in GTP/GDP-binding proteins. The N(T)KXD motif, which is believed to confer guanine...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Line
Child, Preschool
Cloning, Molecular
Consensus Sequence
DNA
GTP-Binding Proteins
Genotype
Guanosine Diphosphate
Guanosine Monophosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Guanosine Triphosphate

Humans

Interferons

Mice

Molecular Sequence Data

Nucleic Acid Hybridization

Source

Open in PubMed Open full text

Identifiers

PMID: 1715024
DOI: 10.1128/mcb.11.9.4717-4725.1991
PMCID: PMC361367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1715024-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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