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Article

Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner.

PloS one - 7 Dec 2010

Britzen-Laurent Nathalie, Bauer Michael, Berton Valeria, Fischer Nicole, Syguda Adrian, Reipschläger Simone, Naschberger Elisabeth, Herrmann Christian, Stürzl Michael

Abstract excerpt

Guanylate-binding proteins (GBPs) belong to the dynamin family of large GTPases and represent the major IFN-γ-induced proteins. Here we systematically investigated the mechanisms regulating the subcellular localization of GBPs. Three GBPs (GBP-1, GBP-2 and GBP-5) carry a C-terminal CaaX-prenylati...

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Identifiers

PMID: 21151871
DOI: 10.1371/journal.pone.0014246
PMCID: PMC2998424

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151871-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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