Article
Genotype Gly/Gly of the Arg16Gly polymorphism of the beta2-adrenergic receptor is associated with elevated fasting serum insulin concentrations, but not with acute insulin response to glucose, in type 2 diabetic patients.
Diabetes research and clinical practice - 1 Jan 2004
Ikarashi Tomoo, Hanyu Osamu, Maruyama Seitaro, Souda Satoshi, Kobayashi Chiaki, Abe Eri, Ukisu Jyunko, Naganuma Keiko, Suzuki Akiko, Toya Maki, Kaneko Susumu, Suzuki Katsunori, Nakagawa Osamu, Aizawa Yoshifusa
Abstract excerpt
The beta(2)-adrenergic receptor (B2AR) is expressed in pancreatic beta-cells and modulates insulin secretion. The purpose of the present study was to evaluate the influence of the Arg16Gly variant allele of B2AR on insulin secretion in patients with type 2 diabetes. We used minimal model analysis of the frequently sampled insulin-modified intravenous glucose tolerance test (FSIGT) and polymerase chain reaction...
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