Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene.

doi:10.1056/NEJM199508103330603

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Article

Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene.

The New England journal of medicine - 10 Aug 1995

Walston J, Silver K, Bogardus C, Knowler W C, Celi F S, Austin S, Manning B, Strosberg A D, Stern M P, Raben N

Abstract excerpt

BACKGROUND: The beta 3-adrenergic receptor is expressed in visceral adipose tissue and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. METHODS: To investigate whether mutations in the gene for the beta 3-adrenergic receptor predispose patients to obesity an...

Topics

Adult
Age of Onset
Aged
Basal Metabolism
Base Sequence
DNA Mutational Analysis
Diabetes Mellitus, Type 2
Gene Frequency
Genotype
Humans
Indians, North American
Middle Aged
Molecular Sequence Data
Obesity

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Point Mutation

Polymorphism, Single-Stranded Conformational

Receptors, Adrenergic, beta

Receptors, Adrenergic, beta-3

Source

Open in PubMed

Identifiers

PMID: 7609750
DOI: 10.1056/NEJM199508103330603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7609750-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.