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Article

Methamphetamine-induced neurotoxicity is attenuated in transgenic mice with a null mutation for interleukin-6.

Molecular pharmacology - 1 Dec 2000

Ladenheim B, Krasnova I N, Deng X, Oyler J M, Polettini A, Moran T H, Huestis M A, Cadet J L

Abstract excerpt

Increasing evidence implicates apoptosis as a major mechanism of cell death in methamphetamine (METH) neurotoxicity. The involvement of a neuroimmune component in apoptotic cell death after injury or chemical damage suggests that cytokines may play a role in METH effects. In the present study, we examined if the absence of IL-6 in knockout (IL-6-/-) mice could provide protection against METH-induced...

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Identifiers

PMID: 11093760
DOI: 10.1124/mol.58.6.1247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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