Article
Sequence variability and candidate gene analysis in complex disease: association of mu opioid receptor gene variation with substance dependence.
Human molecular genetics - 22 Nov 2000
Hoehe M R, Köpke K, Wendel B, Rohde K, Flachmeier C, Kidd K K, Berrettini W H, Church G M
Abstract excerpt
To analyze candidate genes and establish complex genotype-phenotype relationships against a background of high natural genome sequence variability, we have developed approaches to (i) compare candidate gene sequence information in multiple individuals; (ii) predict haplotypes from numerous variants; and (iii) classify haplotypes and identify specific sequence variants, or combinations of variants (pattern),...
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