Article
A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1993
McElreavey K, Vilain E, Abbas N, Herskowitz I, Fellous M
Abstract excerpt
The mammalian Y chromosome carries the SRY gene, which determines testis formation. Here we review data on individuals who are XX but exhibit male characteristics: some have SRY; others do not. We have analyzed three families containing more than one such individual and show that these individuals lack SRY. Pedigree analysis leads to the hypothesis that they carry recessive mutations (in a gene termed Z) that...
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