Article
Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice.
The Journal of veterinary medical science - 1 Jan 2016
Umemura Yuria, Miyamoto Ryosuke, Hashimoto Rie, Kinoshita Kyoko, Omotehara Takuya, Nagahara Daichi, Hirano Tetsushi, Kubota Naoto, Minami Kiichi, Yanai Shogo, Masuda Natsumi, Yuasa Hideto, Mantani Youhei, Matsuo Eiko, Yokoyama Toshifumi, Kitagawa Hiroshi, Hoshi Nobuhiko
Abstract excerpt
Mammalian sexual fate is determined by the presence or absence of sex determining region of the Y chromosome (Sry) in the "bipotential" gonads. Recent studies have demonstrated that both male and female sexual development are induced by distinct and active genetic pathways. Breeding the Y chromosome from Mus m. domesticus poschiavinus (POS) strains into C57BL/6J (B6J) mice (B6J-XY(POS)) has been shown to induce...
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