Article
Nuclear cloning and epigenetic reprogramming of the genome.
Science (New York, N.Y.) - 10 Aug 2001
Rideout W M, Eggan K, Jaenisch R
Abstract excerpt
Cloning of mammals by nuclear transfer (NT) results in gestational or neonatal failure with at most a few percent of manipulated embryos resulting in live births. Many of those that survive to term succumb to a variety of abnormalities that are likely due to inappropriate epigenetic reprogramming. Cloned embryos derived from donors, such as embryonic stem cells, that may require little or no reprogramming of...
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