[From sequence variability to structural and functional prediction: modeling of homologous protein families].

Abstract excerpt

Thanks to next-generation sequencing, the number of sequenced genomes grows rapidly, providing in particular ample examples for the sequence variability between homologous proteins. This article discusses data-driven probabilistic sequence models, which are able to extract a multitude of information from sequence data alone, including (i) structural features like residue-residue contacts, which are formed in the...

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