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Article

A stochastic evolutionary model for protein structure alignment and phylogeny.

Molecular biology and evolution - 1 Nov 2012

Challis Christopher J, Schmidler Scott C

Abstract excerpt

We present a stochastic process model for the joint evolution of protein primary and tertiary structure, suitable for use in alignment and estimation of phylogeny. Indels arise from a classic Links model, and mutations follow a standard substitution matrix, whereas backbone atoms diffuse in three-dimensional space according to an Ornstein-Uhlenbeck process. The model allows for simultaneous estimation of...

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PMID: 22723302
DOI: 10.1093/molbev/mss167
PMCID: PMC3697813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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