Article
Preferential amplification is minimised in long-PCR systems.
Mutation research - 30 Nov 2000
Kopsidas G, Kovalenko S A, Islam M M, Gingold E B, Linnane A W
Abstract excerpt
The advent of long PCR (XL-PCR) has proven to be a major advance in PCR technology and is currently being utilised to investigate numerous biological systems. The analysis of mixed DNA populations is a particularly useful application for XL-PCR. For example, XL-PCR has been used to investigate the occurrence of heterogeneous mitochondrial DNA (mtDNA) rearrangement mutations. With XL-PCR it became possible to...
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