Article

Nanomito enables amplification-free full-length analysis of mitochondrial DNA variants and deletions

2026-07-10

Abstract excerpt

<title>Abstract</title> <p>Accurate analysis of mitochondrial DNA (mtDNA) requires reliable quantification of heteroplasmy and robust detection of large-scale deletions. However, routine PCR-based short-read workflows can introduce amplification bias and have limited structural resolution. Here, we developed Nanomito, an amplification-free long-read workflow for full-length sequencing of native mtDNA using Oxford...

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Literature Corpus work: 27d00476-a283-5cdc-8c41-aafa169ceedd
DOI: 10.21203/rs.3.rs-10113992/v1

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