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Article

Evaluating sequence-derived mtDNA length heteroplasmy by amplicon size analysis.

Forensic science international. Genetics - 1 Mar 2011

Berger C, Hatzer-Grubwieser P, Hohoff C, Parson W

Abstract excerpt

Length heteroplasmy (LH) in mitochondrial (mt)DNA is usually observed in homopolymeric tracts and manifest as mixture of various length variants. The generally used difference-coded annotation to report mtDNA haplotypes does not express the degree of LH variation present in a sample, even more so, it is sometimes difficult to establish which length variants are present and clearly distinguishable from background...

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Identifiers

PMID: 21067985
DOI: 10.1016/j.fsigen.2010.10.002
PMCID: PMC3064993

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