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Article

The structure of the C4C4 ring finger of human NOT4 reveals features distinct from those of C3HC4 RING fingers.

The Journal of biological chemistry - 30 Mar 2001

Hanzawa H, de Ruwe M J, Albert T K, van Der Vliet P C, Timmers H T, Boelens R

Abstract excerpt

The NOT4 protein is a component of the CCR4.NOT complex, a global regulator of RNA polymerase II transcription. Human NOT4 (hNOT4) contains a RING finger motif of the C(4)C(4) type. We expressed and purified the N-terminal region of hNOT4 (residues 1-78) encompassing the RING finger motif and determined the solution structure by heteronuclear NMR. NMR experiments using a (113)Cd-substituted hNOT4 RING finger...

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Source

Identifiers

PMID: 11087754
DOI: 10.1074/jbc.M009298200

Genes

CCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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