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Article

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.

The EMBO journal - 16 Feb 1998

Liu H Y, Badarinarayana V, Audino D C, Rappsilber J, Mann M, Denis C L

Abstract excerpt

The CCR4 transcriptional regulatory complex consisting of CCR4, CAF1, DBF2 and other unidentified factors is one of several groups of proteins that affect gene expression. Using mass spectrometry, we have identified the 195, 185 and 116 kDa species which are part of the CCR4 complex. The 195 and 185 kDa proteins were found to be NOT1 and the 116 kDa species was identical to NOT3. NOT1, 2, 3 and 4 proteins are...

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Identifiers

PMID: 9463387
DOI: 10.1093/emboj/17.4.1096
PMCID: PMC1170458

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.PMID 9463387Read ↗

Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.Semantic proximity Read ↗

The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.Semantic proximity Read ↗

Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.Semantic proximity Read ↗

The Ccr4-Not complex interacts with the mRNA export machinery.Semantic proximity Read ↗

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.Semantic proximity Read ↗

Multifunctional roles of the mammalian CCR4â€“NOT complex in physiological phenomenaSemantic proximity Read ↗

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domainSemantic proximity Read ↗

Interaction between Not1p, a component of the Ccr4-not complex, a global regulator of transcription, and Dhh1p, a putative RNA helicase.Semantic proximity Read ↗

Characterization of mutations in NOT2 indicates that it plays an important role in maintaining the integrity of the CCR4-NOT complex.Semantic proximity Read ↗

The Not4 E3 ligase and CCR4 deadenylase play distinct roles in protein quality control.Semantic proximity Read ↗

The essential function of Not1 lies within the Ccr4-Not complex.Semantic proximity Read ↗

Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation.Semantic proximity Read ↗

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