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Article

Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts.

Transplantation - 15 Nov 2000

Zand M S, Li Y, Hancock W, Li X C, Roy-Chaudhury P, Zheng X X, Strom T B

Abstract excerpt

BACKGROUND: Several studies suggest that MHC-mismatched allografts reject with a Th1 or Th2 immune response, but these models all have low-level expression of the Th1 cytokines interleukin (IL)-2 and interferon-gamma (IFN-gamma). METHODS: We interbred mice with single targeted gene disruptions for IL-2 and IFN-gamma to establish IL-2 + IFN-gamma double knockout (DKO) mice. Heterotopic cardiac allografts from...

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Identifiers

PMID: 11087156
DOI: 10.1097/00007890-200011150-00019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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