Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo: requirement for beta1 subunit of the IL-12 receptor.

Transplantation - 15 Jun 1999

Piccotti J R, Li K, Chan S Y, Eichwald E J, Bishop D K

Abstract excerpt

BACKGROUND: Interleukin-12 (IL-12) mediates its biologic activities via binding high-affinity receptors on T and natural killer cells. Although emphasis has been placed on the requirement for IL-12Rbeta2 in IL-12 bioactivity, the role of IL-12Rbeta1 is less well defined. The current study evaluated the effects of exogenous IL-12 on alloantigen-specific immune responses and determined the requirement for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Formation
Share to Graft Rejection
Share to Heart Transplantation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-12

Share to Isoantigens

Share to Receptors, Interleukin

Share to Th1 Cells

Share to Transplantation, Homologous

Source

Identifiers

PMID: 10385085
DOI: 10.1097/00007890-199906150-00011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo: requirement for beta1 subunit of the IL-12 receptor.PMID 10385085Read ↗

Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway.Semantic proximity Read ↗

Antibodies to the IL-12 Receptor β2 Chain Mark Human Th1 But Not Th2 Cells In Vitro and In VivoSemantic proximity Read ↗

In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitmentSemantic proximity Read ↗

Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance.Semantic proximity Read ↗

Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity.Semantic proximity Read ↗

IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions.Semantic proximity Read ↗

High-resolution characterization of cytokine-producing alloreactivity in naive and allograft-primed mice.Semantic proximity Read ↗

IFN-gamma up-regulation of IL-12 beta 2 receptor is associated with experimental autoimmune uveitis susceptible B10.A mice, but not in EAU resistant BALB/c mice.Semantic proximity Read ↗

CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses.Semantic proximity Read ↗

A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis.Semantic proximity Read ↗

Molecular complementation of IL-12Rbeta1 deficiency reveals functional differences between IL-12Rbeta1 alleles including partial IL-12Rbeta1 deficiency.Semantic proximity Read ↗

IL-2 Receptor Blockade Inhibits Late, But Not Early, IFN-γ and CD40 Ligand Expression in Human T Cells: Disruption of Both IL-12-Dependent and -Independent Pathways of IFN-γ ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.