Article
The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.
Molecular biology of the cell - 1 Aug 1998
Samejima I, Mackie S, Warbrick E, Weisman R, Fantes P A
Abstract excerpt
The Schizosaccharomyces pombe win1-1 mutant has a defect in the G2-M transition of the cell cycle. Although the defect is suppressed by wis1+ and wis4+, which are components of a stress-activated MAP kinase pathway that links stress response and cell cycle control, the molecular identity of Win1 has not been known. We show here that win1+ encodes a polypeptide of 1436 residues with an apparent molecular size of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.