Article
The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.
Molecular biology of the cell - 1 Aug 1998
Samejima I, Mackie S, Warbrick E, Weisman R, Fantes P A
Abstract excerpt
The Schizosaccharomyces pombe win1-1 mutant has a defect in the G2-M transition of the cell cycle. Although the defect is suppressed by wis1+ and wis4+, which are components of a stress-activated MAP kinase pathway that links stress response and cell cycle control, the molecular identity of Win1...
Topics
- Amino Acid Sequence
- Base Sequence
- Cell Cycle
- Chromosome Mapping
- Enzyme Activation
- Genes, Fungal
- MAP Kinase Kinase Kinases
- Mitogen-Activated Protein Kinase Kinases
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Osmolar Concentration
- Phosphorylation