Article
Efficient expression of the tumor-associated antigen MAGE-3 in human dendritic cells, using an avian influenza virus vector.
Human gene therapy - 1 Nov 2000
Strobel I, Krumbholz M, Menke A, Hoffmann E, Dunbar P R, Bender A, Hobom G, Steinkasserer A, Schuler G, Grassmann R
Abstract excerpt
Dendritic cells (DCs) are the most potent inducers of immune reactions. Genetically modified DCs, which express tumor-associated antigens (TAA), can efficiently induce antitumor immunity and thus have a high potential as tools in cancer therapy. The gene delivery is most efficiently achieved by viral vectors. Here, we explored the capacity of influenza virus vectors to transduce TAA genes. These viruses...
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