Article
Recombinant adenovirus type 5 vectors that target DC-SIGN, ChemR23 and alpha(v)beta3 integrin efficiently transduce human dendritic cells and enhance presentation of vectored antigens.
Vaccine - 30 Jan 2006
Maguire Casey A, Sapinoro Ramil, Girgis Natasha, Rodriguez-Colon Sol M, Ramirez Servio H, Williams Jennifer, Dewhurst Stephen
Abstract excerpt
Recombinant adenoviruses (rAds) represent a promising system for vaccine delivery but transduce dendritic cells (DC) relatively poorly. To address this concern, we used a biotin-avidin linkage to conjugate rAd vectors to ligands which bind with high affinity to selected receptors on DC (ChemR23,...
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