Article
ALT-associated PML bodies are present in viable cells and are enriched in cells in the G2/M phase of the cell cycle
15 Dec 2000
Abstract excerpt
Telomere maintenance is essential for the unlimited proliferative potential of human cells, and hence immortalization. However, a number of tumors, tumor-derived cell lines and in vitro immortalized cell lines have been described that do not express detectable telomerase activity. These lines utilize a mechanism, termed Alternative Lengthening of Telomeres (ALT), to provide telomere maintenance. A subset of the...
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