Article
Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.
Thyroid : official journal of the American Thyroid Association - 1 Oct 2000
Akamizu T, Sale M M, Rich S S, Hiratani H, Noh J Y, Kanamoto N, Saijo M, Miyamoto Y, Saito Y, Nakao K, Bowden D W
Abstract excerpt
In a previous study we identified a microsatellite marker near the thyrotropin receptor (TSHR) gene. Studies with this marker, TSHR-CA, revealed a significant association between autoimmune thyroid disease (AITD) in Japanese patients and one specific allele (allele 1; 180 base pair [bp]) of the microsatellite sequence. In addition, weak evidence for association of AITD with two alleles of the CTLA-4 gene was...
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