Article
Association of the T-cell regulatory gene CTLA4 with Graves' disease and autoimmune thyroid disease in the Japanese.
Journal of human genetics - 1 Jan 2004
Furugaki Koichi, Shirasawa Senji, Ishikawa Naofumi, Ito Kunihiko, Ito Koichi, Kubota Sumihisa, Kuma Kanji, Tamai Hajime, Akamizu Takashi, Hiratani Hitomi, Tanaka Masao, Sasazuki Takehiko
Abstract excerpt
Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 ( CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. Recently, AITD susceptibility in the Caucasians was mapped to the 6.1-kb 3'UTR of the CTLA4 gene, in which the three single-nucleotide polymorphisms...
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