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Article

Multiple SNPs in intron 7 of thyrotropin receptor are associated with Graves' disease.

The Journal of clinical endocrinology and metabolism - 1 May 2005

Hiratani Hitomi, Bowden Donald W, Ikegami Satoshi, Shirasawa Senji, Shimizu Akira, Iwatani Yoshinori, Akamizu Takashi

Abstract excerpt

Our previous studies using microsatellite markers near or in the TSH receptor (TSHR) gene revealed significant association between autoimmune thyroid disease (AITD) in Japanese patients and TSHR microsatellite alleles. In the present study, we performed a case-control analysis of AITD using single-nucleotide polymorphisms (SNPs) spaced 3-50 kb apart spanning the TSHR gene. We observed significant associations...

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Identifiers

PMID: 15741259
DOI: 10.1210/jc.2004-2148

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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