Article
Random mutagenesis-PCR to introduce alterations into defined DNA sequences for validation of SNP and mutation detection methods.
Human mutation - 1 Mar 2001
Nickerson M L, Warren M B, Zbar B, Schmidt L S
Abstract excerpt
Sensitive and high throughput techniques are required for the detection of DNA sequence variants such as single nucleotide polymorphisms (SNPs) and mutations. One problem, common to all methods of SNP and mutation detection, is that experimental conditions required for detection of DNA sequence v...
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