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Article

The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells.

The Journal of biological chemistry - 16 Feb 2001

Liu X W, Gong L J, Guo L Y, Katagiri Y, Jiang H, Wang Z Y, Johnson A C, Guroff G

Abstract excerpt

Recently, we characterized the rat epidermal growth factor receptor (EGFR) promoter and demonstrated that TCC repeat sequences are required for the down-regulation of EGFR by nerve growth factor (NGF) in PC12 cells. In this study, we report that the Wilms' tumor gene product WT1, a zinc finger tr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins pp60(c-src)

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Share to Repetitive Sequences, Nucleic Acid

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Source

Identifiers

PMID: 11071895
DOI: 10.1074/jbc.M008776200

Genes

EGFR
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11071895-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Wilms' tumor gene product WT1 mediates the down-regulation of the rat epidermal growth factor receptor by nerve growth factor in PC12 cells.PMID 11071895Read ↗

NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells.Semantic proximity Read ↗

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The Wilms' Tumor 1 Tumor Suppressor Gene Represses Transcription of the Human Telomerase Reverse Transcriptase GeneSemantic proximity Read ↗

Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells.Semantic proximity Read ↗

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Regulation of insulin-like growth factor I receptor promoter activity by wild-type and mutant versions of the WT1 tumor suppressor.Semantic proximity Read ↗

Inhibition of Cellular Proliferation by the Wilms’ Tumor Suppressor WT1 Is Associated with Suppression of Insulin-Like Growth Factor I Receptor Gene ExpressionSemantic proximity Read ↗

RNA binding by the Wilms tumor suppressor zinc finger proteins.Semantic proximity Read ↗

Analysis of WT1 target gene expression in stably transfected cell lines.Semantic proximity Read ↗

Loss of p53 induces epidermal growth factor receptor promoter activity in normal human keratinocytes.Semantic proximity Read ↗

Transcriptional regulation of PDGF-A and TGF-beta by +KTS WT1 deletion mutants and a mutant mimicking Denys-Drash syndrome.Semantic proximity Read ↗

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