Article
Vascular endothelial growth factor (VEGF) is suppressed in WT1-transfected LNCaP cells.
Gene expression - 1 Jan 2006
Graham Kylie, Li Wenliang, Williams Bryan R G, Fraizer Gail
Abstract excerpt
The Wilms' tumor suppressor gene product (WT1) regulates expression of growth control genes. Microarray analysis of gene expression profiles of hormone-treated LNCaP prostate cancer cell lines transfected with either wild-type WT1 or a zinc finger mutant form, DDS (R394W), revealed significantly altered patterns of expression. Validation studies using quantitative real-time PCR confirmed the differential...
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