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Article

Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene.

Developmental biology - 15 Nov 2000

Eggenschwiler J T, Anderson K V

Abstract excerpt

The processes that specify early regional identity in dorsal and lateral regions of the mammalian neural tube are not well understood. The mouse open brain (opb) gene plays an essential role in dorsal neural patterning: in the caudal spinal cord of opb mutants, dorsal cell types are absent and markers of ventral fates, including Shh, expand into dorsal regions. Analysis of the opb mutant phenotype and of opb/opb...

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PMID: 11071781
DOI: 10.1006/dbio.2000.9918

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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