Article
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.
Nature - 12 Jul 2001
Eggenschwiler J T, Espinoza E, Anderson K V
Abstract excerpt
The mouse open brain (opb) and Sonic hedgehog (Shh) genes have opposing roles in neural patterning: opb is required for dorsal cell types and Shh is required for ventral cell types in the spinal cord. Here we show that opb acts downstream of Shh. Ventral cell types that are absent in Shh mutants, including the floor plate, are present in Shh opb double mutants. The organization of ventral cell types in Shh opb...
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