Article
Mutation screening of interferon regulatory factor 1 gene (IRF-1) as a candidate gene for atopy/asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2000
Noguchi E, Shibasaki M, Arinami T, Yamakawa-Kobayashi K, Yokouchi Y, Takeda K, Matsui A, Hamaguchi H
Abstract excerpt
BACKGROUND: IL-4 gene cluster on chromosome 5 contains several candidate genes for atopy and asthma. Several independent studies have shown evidence for linkage between the markers flanking IL-4 gene cluster and asthma and/or asthma-related traits. Interferon regulatory factor 1 (IRF-1) is located approximately 300 kb telomeric to IL-4 and recent study reveals that IRF-1 deficiency results in an elevated...
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